Does/How Does Using MicroSD Card in Clip+ Affect Performance?

[Katissima]

I loved my old clip--until I lost it. I'm thinking of replacing it with a clip+ instead I've never had a device with any kind of micro SD card. Does it affect the performance at any time other than the initial database refresh when you insert it? What I mean is, if you are on play all--shuffle, will it lag/stall/pause skipping between songs that are on the clip and songs that are on the card?